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Recent Publications in Peer-reviewed Journals

  • Yang W, Zhou X, Zimmermann HR, Ma T. Brain-specific suppression of AMPKα2 isoform impairs cognition and hippocampal LTP by PERK-mediated eIF2α phosphorylation. 2020, Mol Psychiatry. In press. 

  • Wang X, Zimmermann HR, Lockhart SN, Craft S, Ma T. “Decreased levels of blood AMPKα1 but not AMPKα2 isoform in patients with mild cognitive impairment and Alzheimer’s disease: a pilot study. 2020, J Alzheimers Dis. In press.

  • Zimmermann HR, Yang W, Kasica NP, Zhou X, Beckelman BC, Lee J, Furdui CM, Keene CD,Ma T.Brain-specific repression of AMPKα1 isoform alleviates pathophysiology in Alzheimer’s disease model mice. 2020, J Clin Invest. pii: 133982. doi: 10.1172/JCI133982. [Epub ahead of print] . 

  • Wang X, Zimmermann HR, Ma T (2019). Therapeutic potential of AMP-activated protein kinase in  Alzheimer’s disease . J Alzheimers Dis. 68:33-38.

  • Yang W, Zhou X, Ma T. Memory decline and behavioral inflexibility in aged mice are correlated with dysregulation of protein synthesis capacity. Front Aging Neurosci. 2019. PMID: 31551760.

  • Day SM, Yang W, Stern J, Zhou X, Macauley S, Ma T. Glucagon-like peptide-1 cleavage product improves cognitive function in a mouse model of Down syndrome. eNeuro. 2019. 6:0031-19. PMID: 31040160

  • Beckelman BC, Yang W, Kasica NP, Zimmermann HR, Zhou X, Keene CD, Ryazanov AG, Ma T*. Genetic reduction of eEF2 kinase alleviates pathophysiology in Alzheimer’s disease model mice.          J Clin Invest. 2019 Feb 1; 129:820-833. PMID: 30667373.

  • Zimmermann HR, Yang W, Beckelman BC, Kasica NP, Zhou X, Galli L, Ryazanov AG, Ma T* (2018) Genetic Removal of eIF2α Kinase PERK in Mice Enables Hippocampal L-LTP Independent of mTORC1 Activity. J Neurochem. 146:133-144. PMID: 29337352. Cover article with editorial highlight.

  • Day SM, Yang W, Ewin S, Zhou X, Ma T* (2017). Glucagon-Like Peptide-1 Cleavage Product GLP-1 (9-36) Amide Enhances Hippocampal Long-term Synaptic Plasticity in Correlation with Suppression of Kv4.2 expression and eEF2 Phosphorylation. Hippocampus 27:1264-1274. PMID: 28833775

  • Beckelman BC, Day SM, Zhou X, Donohue M, Gouras GK, Klann E, Keene CD, Ma T* (2016). Dysregulation of elongation factor 1A expression is correlated with synaptic plasticity impairments in Alzheimer’s disease. J Alzheimers Dis. 54:669-678. PMID: 27567813.

  • Yang W, Zhou X, Zimmermann HR, Cavener DR, Klann E, Ma T* (2016). Repression of the eIF2α kinase PERK alleviates mGluR-LTD impairments in a mouse model of Alzheimer's disease. Neurobiol Aging. 2016 May;41:19-24. PubMed PMID: 27103515; PubMed Central PMCID: PMC4841914.

  • Ma T, Chen Y, Vingtdeux V, Zhao H, Viollet B, Marambaud P, Klann E (2014) Inhibition of AMP-activated protein kinase signaling alleviates impairments in hippocampal synaptic plasticity induced by amyloid β.J Neurosci 34: 12230-12238 (paper of the week).   PMID: 25186765. PMCID: PMC4152616. 


  • Ma T and Klann E (2014) PERK: a novel therapeutic target for neurodegenerative diseases? Alzheimers Res Ther. 29:30. PMID: 25031640. PMCID: PMC4075240.

  • Trinh MA*, Ma T*, Kaphzan H, Bhattacharya A, Antion MD, Cavener DR, Hoeffer CA, Klann E (2014) The eIF2α kinase PERK limits the expression of hippocampal metabotropic glutamate receptor-dependent long-term depression. Learn Mem. 21:298-304. (*equal contribution, co-first author). PMID: 24741110. PMCID: PMC 3994503.

  • Kurinami H, Shimamura M, Ma T, Liping Qian, Kenzo Koizumi, Laibaik Park, Eric Klann, Giovanni Manfredi, Costantino Iadecola, Ping Zhou (2014) Prohibitin viral gene transfer protects hippocampal CA1 neurons from ischemia-reperfusion and rescues hippocampal function . Stroke. 45:1131-1138. PMID: 24619393. PMCID: PMC3971834.

  • Ma T (2014) GSK3 in Alzheimer’s Disease – Mind the Isoforms. J Alzheimers Dis.  39:707-710. PMID:24254703.

  • Hoeffer CA, Santini E, Ma T, Arnold E, Whelan A, Wong H, Pierre P, Pelletier J, Klann E (2012) Multiple components of eIF4F are required for protein synthesis-dependent hippocampal long-term potentiation. J Neurophysiol 109:68-76. PMID: 23054596. PMCID: PMC3545154

  • Ma T, Trinh MA, Wexler AJ, Bourbon C, Gatti E, Pierre P, Cavener DR, Klann E (2013) Suppression of PERK-eIF2α signaling alleviates synaptic plasticity and spatial memory deficits in Alzheimer's disease model mice. Nat Neurosci. 16:1299-1305. PMID: 23933749. PMCID: PMC3756900.

  • Ma T, Du X, Pick J, Sui G, Brownlee M, Klann E (2012) Glucagon-like peptide-1 cleavage product GLP-1 (9-36) amide rescues synaptic plasticity and memory deficits in Alzheimer's Disease model mice. J Neurosci. 32: 13701-13708 (paper of the week). PMID: 23035082.  PMCID: PMC3475870.  

  • Ma T and Klann E (2012) Amyloid β: linking synaptic plasticity failure to memory disruption in Alzheimer’s Disease. J Neurochem 120 Suppl 1: 140-148. PMID: 22122128. PMCID: PMC3254830.

  • Ma T, Tzavaras N, Tsokas P, Landau EM, Blitzer RD (2011) Synaptic stimulation of mTOR is mediated by Wnt signaling and regulation of glycogen synthetase kinase-3. J Neurosci 31: 17537-17546 (cover paper). PMID: 22131415.

  • Ma T*, Hoeffer CA*, Wong H, Massaad CA, Zhou P,  Iadecola C, Murphy MP, Paulter RG, Klann E (2011) Amyloid beta-induced Impairments in hippocampal synaptic plasticity are rescued by decreasing mitochondrial superoxide. J Neurosci 31: 5589-5595 (paper of the week * equal contribution, co-first author). PMID: 21490199; PMCID: PMC3095121

  • Ma T, Hoeffer CA, Capetillo-Zarate E, Yu F, Wong H, Lin MT, Tampellini D, Klann E, Blitzer RD, Gouras GK (2010) Dysregulation of the mTOR pathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer's disease.  PLoS One. 5. pii: e12845. PMID: 20862226; PMCID: PMC2942840

  • Tampellini D, Rahman N, Gallo EF, Huang Z, Dumont M, Capetillo-Zarate E, Ma T, Zheng R, Lu B, Nanus DM, Lin MT, Gouras GK (2009) Synaptic activity reduces intraneuronal Abeta, promotes APP transport to synapses, and protects against Abeta-related synaptic alterations. J Neurosci 29:9704-9713. PMID: 19657023; PMCID: PMC2763626

  • Tsokas P*, Ma T*, Iyengar R, Landau EM, Blitzer RD (2007) Mitogen-activated protein kinase upregulates the dendritic translation machinery in long-term potentiation by controlling the mammalian target of rapamycin pathway. J Neurosci 27: 5885 - 5894 (* equal contribution, co-first author). PMID: 17537959.

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